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PORPHYRIN-METAL CHELATASE
Descriptors Found:
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DeCS
Descriptor
English
:
Ferrochelatase
Descriptor
Spanish
:
Ferroquelatasa
Descriptor
Portuguese
:
Ferroquelatase
Synonyms
English
:
Heme Synthetase
Porphyrin-Metal Chelatase
Tree Number:
D08.811.520.500
D12.776.157.427.374.375.957
D12.776.556.579.374.375.617
D12.776.575.562
Definition
English
:
A mitochondrial enzyme found in a wide variety of cells and
tissues
. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME.
Ferrochelatase
catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in
ERYTHROPOIETIC PROTOPORPHYRIA.
Entry Combination - descr/qualif
English
:
Ferrochelatase
/
deficiency
use
Protoporphyria, Erythropoietic
History Note
English
:
1991(1977); use LYASES 1977-1990
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
5403
Unique Identifier:
D005294
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS